Reacción #44153

Ecuación de reacción

3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline

triethylamine

methanesulfonyl chloride

→

title compound

N-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-N-(methylsulfonyl)methanesulfonamide

Disolventes

DCM

Condiciones de reacción

Tratamiento posterior

1. 1
   Otropartitioned between saturated aqueous sodium hydrogencarbonate solution and DCM
2. 2
   LavadoThe organic layer was washed with water
3. 3
   Otrodried
4. 4
   Concentraciónconcentrated in vacuo
5. 5
   OtroThe residue was purified by column chromatography [SiO2; DCM-MeOH, (20:0)→(20:1)]

Procedimiento

To a stirred solution of 3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline (370 mg) and triethylamine (178 μL) in DCM (3 mL) was added methanesulfonyl chloride (33 L). The mixture was stirred for 18 h, then partitioned between saturated aqueous sodium hydrogencarbonate solution and DCM. The organic layer was washed with water, dried and concentrated in vacuo. The residue was purified by column chromatography [SiO2; DCM-MeOH, (20:0)→(20:1)] to give the title compound (342 mg).

Fuente