Reacción #44139

Ecuación de reacción

sodium hydride

1-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone

methyl iodide

→

final compound

Rendimiento 45.0%

1-Methyl-3-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone

Rendimiento 45.0%

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadoeluted with methanol
2. 2
   ConcentraciónThe basic fractions were concentrated under vacuum
3. 3
   Otropurified by column chromatography (SPE cartridge, Silica)

Procedimiento

To a stirred solution of 1-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone (E85) in THF was added methyl iodide (1 eq.), followed by sodium hydride (1.2 eq), and the reaction was stirred for 60 minutes. The mixture was loaded onto an ion-exchange cartridge (SCX-2) and eluted with methanol followed by ammonia in methanol (1M). The basic fractions were concentrated under vacuum and purified by column chromatography (SPE cartridge, Silica) using as eluent a gradient from DCM-methanol (99:1) to DCM-methanol (98:2) affording the final compound (45% yield).

Fuente