Reacción #440831

Ecuación de reacción

acetophenone

dimethylamine hydrochloride

1,3-dioxolane

hydrochloric acid

→

3-dimethylamino-1-phenylpropan-1-one

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONare added
2. 2
   Temperaturathe mixture is heated to exactly 90° C.
3. 3
   Temperaturamaintained at that temperature for 3.5 hours
4. 4
   workup.DISTILLATIONExcess dioxolane is distilled off

Procedimiento

30.0 g of acetophenone are mixed with 24.5 g of dimethylamine hydrochloride and 74.1 g of 1,3-dioxolane, 2.5 g of concentrated hydrochloric acid are added, and the mixture is heated to exactly 90° C. and maintained at that temperature for 3.5 hours. Excess dioxolane is distilled off and the residue is cooled to 0° C. The resulting 3-dimethylamino-1-phenylpropan-1-one of formula

Fuente