Reacción #44050

Ecuación de reacción

ammonium chloride

2-methyl-5-{4-[2-(3-nitrophenyl)ethyl]-1-piperazinyl}quinoline

2-Methyl-5-{4-[2-(3-nitrophenyl)ethyl]-1-piperazinyl}quinoline

ammonium chloride

→

title compound

Rendimiento 84.0%

3-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline

Rendimiento 84.0%

Disolventes

methanol

water

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reactants were heated
2. 2
   Temperaturaat reflux for 8 hours
3. 3
   Otroduring the reaction
4. 4
   FiltraciónThe reaction mixture was filtered
5. 5
   Filtraciónfilter
6. 6
   ConcentraciónThe filtrate was concentrated under reduced pressure
7. 7
   workup.ADDITIONdiluted with water (5 mL)
8. 8
   Extraccióna saturated aqueous solution of sodium hydrogen carbonate (2 mL), extracted into ethyl acetate (3×5 mL)
9. 9
   Secadodried over Na2SO4
10. 10
    Concentraciónconcentrated under reduced pressure

Procedimiento

A solution of 2-methyl-5-{4-[2-(3-nitrophenyl)ethyl]-1-piperazinyl}quinoline (D5) (0.14 g; 1 eq) in methanol (3 mL) was added dropwise to a suspension of iron powder (0.07 g; 3.2 eq) and ammonium chloride (0.1 g; 5.3 eq) in water (3 mL). The reactants were heated at reflux for 8 hours, adding additional amounts of iron powder (total 0.07 g; 3.2 eq) and ammonium chloride (total 0.1 g; 5.03 eq) in 3 portions during the reaction. The reaction mixture was filtered using a Millipore filter. The filtrate was concentrated under reduced pressure, diluted with water (5 mL) and a saturated aqueous solution of sodium hydrogen carbonate (2 mL), extracted into ethyl acetate (3×5 mL), dried over Na2SO4 and concentrated under reduced pressure obtaining the title compound in 84% yield (0.11 g).

Fuente