Reacción #44003

Ecuación de reacción

Methyl 2-aminobutanoate hydrochloride

triethylamine

4-chlorobenzenesulfonyl chloride

→

product 57

methyl 2-(4-chlorophenylsulfonamido)butanoate

Disolventes

CH2Cl2

CH2Cl2

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadowashed with water (3×50 mL), sat. NaHCO3 (2×50 mL), brine (50 mL)
2. 2
   Secadodried (MgSO4)
3. 3
   OtroThe solvent was removed by rotary evaporation

Procedimiento

Methyl 2-aminobutanoate hydrochloride 56 (25 g, 0.163 mol) was suspended in CH2Cl2 (100 mL) and triethylamine (50 mL) and 4-chlorobenzenesulfonyl chloride (37.8 g, 1.1 eq) were added to the mixture. The mixture was stirred at room temperature overnight. Diluted with 200 mL of CH2Cl2 and washed with water (3×50 mL), sat. NaHCO3 (2×50 mL), brine (50 mL) and dried (MgSO4). The solvent was removed by rotary evaporation to give the product 57 as a yellow oil. LCMS 292.0 (M+H).

Fuente