Reacción #43938

Ecuación de reacción

4-bromo-3,5-dimethylphenol

3-(methylthio)-1-propanol

tributylphosphine

1,1′-(azodicarbonyl)dipiperidine

→

title compound

Rendimiento 87.0%

2-bromo-1,3-dimethyl-5-[3-(methylthio)propoxy]benzene

Rendimiento 87.0%

Disolventes

Hexane

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   Filtraciónthe insoluble substance was filtered off
2. 2
   Concentraciónthe filtrate was concentrated under reduced pressure
3. 3
   OtroThe residue was purified by silica gel column chromatography (ethyl acetate:hexane=0:100-25:75)

Procedimiento

To a solution of 4-bromo-3,5-dimethylphenol (4.02 g, 20.0 mmol), 3-(methylthio)-1-propanol (2.12 g, 20.0 mmol) and tributylphosphine (7.97 mL, 32.0 mmol) in toluene (320 mL) was added 1,1′-(azodicarbonyl)dipiperidine (8.07 g, 32.0 mmol), and the mixture was stirred at room temperature for 18 hr under nitrogen atmosphere. Hexane (160 mL) was added to the reaction mixture, the insoluble substance was filtered off, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:hexane=0:100-25:75) to give the title compound (5.03 g, yield 87%) as a pale-yellow oil.

Fuente