Reacción #43926

Ecuación de reacción

4-bromo-3,5-dimethylphenol

acetic anhydride

→

title compound

Rendimiento 128.9%

4-bromo-3,5-dimethylphenyl acetate

Rendimiento 128.9%

Disolventes

hydrochloric acid

pyridine

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturacooled
2. 2
   Extracciónextracted with ethyl acetate
3. 3
   LavadoThe extract was washed with saturated brine
4. 4
   Secadodried over anhydrous magnesium sulfate
5. 5
   Concentraciónconcentrated under reduced pressure

Procedimiento

To a solution of 4-bromo-3,5-dimethylphenol (10.1 g, 50.0 mmol) in pyridine (13 mL) was added acetic anhydride (7.66 g, 38.6 mmol), and the mixture was stirred at 50° C. for 30 min. The reaction mixture was ice-cooled, diluted with 0.5 M hydrochloric acid, and extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give the title compound (12.1 g, yield 99%) as a yellow oil.

Fuente