Reacción #43887
ord-b6399fa9765c47cd9c2f163023dd8697
Ecuación de reacción
2,7-Biscarboethoxyamino-9-phenylphenanthridine
3-bromopropionic acid
→
product 22-2
10-Carboxyethyl-2,7-biscarboethoxyamino-9-phenylphenanthridine
Reactivos
Ninguno
Disolventes
Condiciones de reacción
Condiciones detalladas
See reaction.notes.procedure_details.
Tratamiento posterior
- 1Otrois precipitated by addition of ether
Procedimiento
2,7-Biscarboethoxyamino-9-phenylphenanthridine (22-1, 1 equiv.), prepared by the method of Watkins (1952) J. Chem. Soc. 3059, is combined with 3-bromopropionic acid (2.5 equiv.; Aldrich Chemical Co., Milwaukee, Wis.) and is heated in nitrobenzene at 100° C. for 4-6 hours. Following cooling to room temperature the crude product is precipitated by addition of ether. The product 22-2 is isolated by filtration and used directly.