Reacción #43868

Ecuación de reacción

4-Chloro-benzoyl chloride

(5-benzylamino-2-propyl-benzoimidazol-1-yl)-acetic acid tert-butyl ester

DIEA

→

subtitle compound

{5-[Benzyl-(4-chloro-benzoyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester

Disolventes

HCl

CH2Cl2

Condiciones de reacción

Tratamiento posterior

1. 1
   Filtraciónfiltered through an Extrelut column
2. 2
   LavadoThe Extrelut column was washed with CH2Cl2
3. 3
   Concentraciónthe filtrate was concentrated

Procedimiento

4-Chloro-benzoyl chloride (46 μL, 0.36 mmol) was added to a solution of (5-benzylamino-2-propyl-benzoimidazol-1-yl)-acetic acid tert-butyl ester (45 mg, 0.12 mmol), DIEA (41 μL, 0.24 mmol) and DMAP (15 mg, 0.12 mmol) in CH2Cl2 (1 mL), and stirred overnight at room temperature. The reaction solution was diluted with aqueous HCl (1.0 M) and filtered through an Extrelut column. The Extrelut column was washed with CH2Cl2, and the filtrate was concentrated to afford the subtitle compound that was used without further purification. MS calculated for C30H32ClN3O3+H: 518, observed: 518.

Fuente