Reacción #438654

ord-f6d34c641b1243a29109d6ee9583ad21

Ecuación de reacción

CC(C)(C)OC(=O)NC(C)(C)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN2C(=O)N(CC(F)(F)F)C(=O)[C@]2(Cc2ccccn2)C1
compound
CC(C)(C)OC(=O)NC(C)(C)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN2C(=O)N(CC(F)(F)F)C(=O)[C@]2(Cc2ccccn2)C1
(1-{1(R)-[1,3-Dioxo-8a(S)-Pyridin-2-Ylmethyl-2-(2,2,2-Trifluoro-Ethyl)-Hexahydro-Imidazo[1,5-a]Pyrazine-7-Carbonyl]-4-Phenyl-Butylcarbamoyl}-1-Methyl-Ethyl)-Carbamic Acid Tert-Butyl Ester
Cl
HCl
→
CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN2C(=O)N(CC(F)(F)F)C(=O)[C@]2(Cc2ccccn2)C1.Cl
2-Amino-N-{1(R)-[1,3-Dioxo-8a(S)-Pyridin-2-Ylmethyl-2-(2,2,2-Trifluoro-Ethyl)-Hexahydro-Imidazo[1,5-a]Pyrazine-7-Carbonyl]-4-Phenyl-Butyl}-2-Methyl-Propionamide, Hydrochloride

Reactantes

CC(C)(C)OC(=O)NC(C)(C)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN2C(=O)N(CC(F)(F)F)C(=O)[C@]2(Cc2ccccn2)C1
compound
CC(C)(C)OC(=O)NC(C)(C)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN2C(=O)N(CC(F)(F)F)C(=O)[C@]2(Cc2ccccn2)C1
(1-{1(R)-[1,3-Dioxo-8a(S)-Pyridin-2-Ylmethyl-2-(2,2,2-Trifluoro-Ethyl)-Hexahydro-Imidazo[1,5-a]Pyrazine-7-Carbonyl]-4-Phenyl-Butylcarbamoyl}-1-Methyl-Ethyl)-Carbamic Acid Tert-Butyl Ester
Cl
HCl

Reactivos

Ninguno

Disolventes

CCO
EtOH

Condiciones de reacción

Temperatura
0°CELSIUS
Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    Concentraciónconcentrated down

Procedimiento

To a solution of the compound of Example 199, Step D (73 mg) in EtOH (5 mL, 0° C.) was added conc. HCl (0.5 mL). The solution was stirred at 0° C. for 1 h and concentrated down to deliver 68 mg of Example 199, Step E:+APcl MS (M+1)+ 589; 1H NMR=400 MHz (CD3OD) δ: 8.36 (d, 1H), 4.86 (br m, 3H), 1.44 (s, 3H), 1.42 (s, 3H).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: USRE038524E1uspto-grants-2004_06