Reacción #43844

Ecuación de reacción

4-Trifluoromethoxybenzyl bromide

K2CO3

[5-(4-fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester

→

{5-[(4-Trifluoromethoxy-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester

Disolventes

EtOAc

H2O

CH3CN

Condiciones de reacción

Tratamiento posterior

1. 1
   Filtraciónfiltered through an Extrelut column
2. 2
   LavadoThe column was washed with EtOAc
3. 3
   Concentraciónthe filtrate was concentrated
4. 4
   OtroThe crude product was carried onto the next reaction without any further purification or characterization

Procedimiento

4-Trifluoromethoxybenzyl bromide (0.27 mmol) and K2CO3 (63 mg, 0.45 mmol) were added to a solution of [5-(4-fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester (40 mg, 0.09 mmol) in CH3CN (1 mL), and stirred overnight at 80° C. The reaction mixture was diluted with EtOAc and H2O, and then filtered through an Extrelut column. The column was washed with EtOAc, and the filtrate was concentrated. The crude product was carried onto the next reaction without any further purification or characterization.

Fuente