Reacción #437855

Ecuación de reacción

dibutyltin dilaurate

(R)-mandelic acid

4-chlorophenyl isocyanate

water

→

(R)-(4-chlorophenylcarbamoyloxy)phenylacetic acid

Disolventes

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextracted with ethyl acetate
2. 2
   OtroThe organic phase is evaporated

Procedimiento

1.1 400 mg (0.63 mmol) of dibutyltin dilaurate are added to a solution of 10.0 g (65.7 mmol) of (R)-mandelic acid and 10.0 g (65.1 mmol) of 4-chlorophenyl isocyanate in 100 ml of dichloromethane, and the mixture is stirred at room temperature for 24 hours. The reaction mixture is introduced into water and extracted with ethyl acetate. The organic phase is evaporated, giving (R)-(4-chlorophenylcarbamoyloxy)phenylacetic acid as a colourless solid; ESI 306.

Fuente