Reacción #43771

Ecuación de reacción

(S)-2-bromophenylalanine

K2CO3

→

(S)-2,3-dihydro-1H-indole-2-carboxylic acid

Disolventes

NMP

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe reactor was flushed with argon

Procedimiento

A flask was charged successively with 366 mg (1.5 mmol) (S)-2-bromophenylalanine, 217 mg (1.6 mmol) K2CO3, 3.2 mg (0.03 mmol) CuCl and 3.2 g NMP. The reactor was flushed with argon and then kept under a slow stream of argon. The reaction mixture was stirred and heated until 100° C. and kept at this temperature. Samples were taken regularly and analyzed by HPLC. After 4 hours, full conversion of (S)-2-bromophenylalanine was found. The yield (measured in solution) of (S)-2,3-dihydro-1H-indole-2-carboxylic acid was 95.9%, ee>98.6%.

Fuente