Reacción #4377

Ecuación de reacción

iodine

1-(3-methoxyphenyl)butane-3-one

→

1-(2-iodo-5-methoxyphenyl)butane-3-one

Rendimiento 82.3%

Disolventes

acetic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe silver iodide was removed by filtration
2. 2
   Lavadowashed with acetic acid
3. 3
   OtroThe filtrate was partitioned between ether and water
4. 4
   LavadoThe ether layer was washed with water, sodium bicarbonate solution and sodium thiosulfate solution
5. 5
   SecadoThe ether solution was dried with MgSO4
6. 6
   Otroevaporated to dryness in vacuo

Procedimiento

Samples of iodine (42.4 g, 0.167 mole) and silver acetate (27.87 g, 0.167 mole) were added in portions to a solution of 29.8 g (0.167 mole) of 1-(3-methoxyphenyl)butane-3-one in 167 ml of glacial acetic acid. The mixture was stirred one hour. The silver iodide was removed by filtration and washed with acetic acid. The filtrate was partitioned between ether and water. The ether layer was washed with water, sodium bicarbonate solution and sodium thiosulfate solution. The ether solution was dried with MgSO4 and evaporated to dryness in vacuo. There was obtained 41.8 g (82% yield) of oily 1-(2-iodo-5-methoxyphenyl)butane-3-one.

Fuente