Reacción #4376

Ecuación de reacción

3-methoxybenzeneacetic acid

iodine monochloride

water

→

2-iodo-5-methoxybenzeneacetic acid

Rendimiento 65.0%

Disolventes

acetic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe solid collected
2. 2
   OtroIt was recrystallized from toluene

Procedimiento

A solution of 45 g (0.27 mole) of 3-methoxybenzeneacetic acid, 52.6 g (0.32 mole) of iodine monochloride and 1 g of iodine was allowed to stand in 500 ml of glacial acetic acid for six days at room temperature. The reaction was poured into water and the solid collected. It was recrystallized from toluene to give 51 g of crystalline 2-iodo-5-methoxybenzeneacetic acid, mp 133.5°-134.5° C. (65% yield).

Fuente