Reacción #43599
ord-d7c270c11b2d48df9ab6c3a0d6b5eae8
Ecuación de reacción
4-[(4-amino-1-piperidinyl)methyl]-3-chloro-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one
3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carboxaldehyde
→
title compound
Rendimiento 69.0%
3-Chloro-4-[(4-{[(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)methyl]amino}-1-piperidinyl)methyl]-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one Hydrochloride
Rendimiento 69.0%
Reactantes
Reactivos
Ninguno
Condiciones de reacción
Condiciones detalladas
See reaction.notes.procedure_details.
Procedimiento
The free base of the title compound was synthesised from 4-[(4-amino-1-piperidinyl)methyl]-3-chloro-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one and 3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carboxaldehyde (for a synthesis see WO2002056882, Example 5(b)), according to the general method of Example 2(h), in 69% yield.