Reacción #43551

Ecuación de reacción

title compound

[1-(R)-Benzyloxymethyl-2-(5-fluoro-2,3-dihydro-indol-1-yl)-ethyl]-carbamic acid 1-(S)-cyclohexylmethyl-2-morpholin-4-yl-2-oxo-ethyl ester

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title compound

Rendimiento 71.4%

[2-(5-Fluoro-2,3-dihydro-indol-1-yl)-1-(R)-hydroxymethyl-ethyl]-carbamic acid 1-(S)-cyclohexylmethyl-2-morpholin-4-yl-2-oxo-ethyl ester

Rendimiento 71.4%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroAir was purged from the reaction vessel and H2 gas
2. 2
   workup.ADDITIONwas introduced via a balloon
3. 3
   FiltraciónThe Pd/C was filtered
4. 4
   Otrothe crude material was purified by reverse-phase HPLC

Procedimiento

The title compound of Example 10 (50 mg, 0.088 mmol) was dissolved in a minimum amount of methanol (approx. 1-2 mL) and a catalytic amount of 10% Pd/C was added. Air was purged from the reaction vessel and H2 gas was introduced via a balloon. The reaction mixture was stirred for several hours under a H2 atmosphere, after which point the starting material had disappeared by LCMS. The Pd/C was filtered and the crude material was purified by reverse-phase HPLC to afford the title compound (30 mg, 71% yield).

Fuente