Reacción #434962

Ecuación de reacción

2-chlorophenylacetic acid

MeOH

→

methyl (2-chlorophenyl)acetate

Rendimiento 97.5%

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe solution was refluxed for 16 hours
2. 2
   ConcentraciónAfter concentration
3. 3
   Lavadowashed with sat'd aq. NaHCO3, H2O and brine
4. 4
   SecadoThe organic layer was dried over Na2SO4
5. 5
   Concentraciónconcentrated

Procedimiento

To 2-chlorophenylacetic acid (1.04 g, 6 mmol) in MeOH (25 mL) was added sulfuric acid (6 drops) and the solution was refluxed for 16 hours. After concentration, the residue was taken up in ethyl acetate and washed with sat'd aq. NaHCO3, H2O and brine. The organic layer was dried over Na2SO4 and concentrated to give methyl (2-chlorophenyl)acetate 6a (1.08 g, 97.5% ) as a yellowish oil. GCMS (EI) m/z 184, 186 (M+).

Fuente