Reacción #43446

Ecuación de reacción

bromomaleic anhydride

Hydrazine sulphate salt

bromomaleic anhydride

hydrazine sulphate

→

4-bromo-1,2-dihydro-3,6-pyridazinedione

Rendimiento 151.0%

Disolventes

water

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaheated
2. 2
   Temperaturato reflux
3. 3
   TemperaturaThe mixture was heated
4. 4
   Temperaturaat reflux for 4 hours
5. 5
   FiltraciónThe precipitates were collected by filtration
6. 6
   Lavadowashed with water and acetone
7. 7
   Otrodried as a combined batch in vacuo

Procedimiento

Hydrazine sulphate salt (51 g) was suspended in water (250 ml), heated to reflux and bromomaleic anhydride (90.38 g) was added dropwise. The mixture was heated at reflux for 4 hours then cooled to room temperature. The reaction was repeated with 29 g hydrazine sulphate, 53 g bromomaleic anhydride and 130 ml water. The precipitates were collected by filtration, washed with water and acetone and dried as a combined batch in vacuo to afford 4-bromo-1,2-dihydro-3,6-pyridazinedione as a white solid (113 g).

Fuente