Reacción #434159

Ecuación de reacción

6-(4-chlorobenzoyl)-4-(3-chlorophenyl)-2(1H)-quinolinone

phosphoryl chloride

→

[2-chloro-4(3-chlorophenyl)-6-quinolinyl](4-chlorophenyl)-methanone hydrochloride

Rendimiento 100.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGstirred further at 70° C. for one night
2. 2
   Otroevaporated till dryness

Procedimiento

A mixture of 6-(4-chlorobenzoyl)-4-(3-chlorophenyl)-2(1H)-quinolinone (0.127 mol), described in International Patent Specification WO 97/21701, in phosphoryl chloride (125 ml) was stirred and heated at 40° C. for one night, stirred further at 70° C. for one night and evaporated till dryness, yielding (100%) of [2-chloro-4(3-chlorophenyl)-6-quinolinyl](4-chlorophenyl)-methanone hydrochloride (1:1) (intermediate 55).

Fuente