Reacción #43400

Ecuación de reacción

3-chloro-6-(methyloxy)-1,5-naphthyridin-4(1H)-one

3-chloro-6-(methoxy)-1,5-naphthyridin-4-ol

water

potassium carbonate

phosphorous tribromide

→

desired compound

Rendimiento 91.0%

8-Bromo-7-chloro-2-(methyloxy)-1,5-naphthyridine

Rendimiento 91.0%

Disolventes

N,N-dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroat 0° C.
2. 2
   workup.WAITat 25° C. for 1 hour
3. 3
   OtroThe solid formed
4. 4
   Filtraciónwas filtered off
5. 5
   Lavadowashed with water
6. 6
   Otrodried in vacuo

Procedimiento

To a solution of 3-chloro-6-(methyloxy)-1,5-naphthyridin-4(1H)-one (3-chloro-6-(methoxy)-1,5-naphthyridin-4-ol, for a synthesis see WO2004058144, Example 1(a)) (43 g, 204.8 mmol) in N,N-dimethylformamide (500 ml) at 0° C. was added phosphorous tribromide dropwise (23.3 ml, 245.8 mmol). The reaction mixture was then stirred at 10° C. for 0.5 hour and then at 25° C. for 1 hour. The mixture was then poured onto 1600 ml of water and basified to pH 7 with potassium carbonate. The solid formed was filtered off, washed with water and dried in vacuo to afford the desired compound (51 g, 91%).

Fuente