Reacción #43384

ord-999da6e8184f4319ab6c7c3fc944720f

Ecuación de reacción

O=C(O)c1ccc(Br)s1
5-bromo-thiophene-2-carboxylic acid
Cc1cc(NC(=O)[C@H](N)Cc2c[nH]cn2)ccc1C(=O)N1CCCC1
(R)-2-amino-3-(1H-imidazol-4-yl)-N-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenyl]-propionamide
CN1CCOCC1
NMM
Cc1cc(NC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)c2ccc(Br)s2)ccc1C(=O)N1CCCC1
5-bromo-thiophene-2-carboxylic acid-N-{(1R)-2-[1H-imidazol-4-yl]-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide

Disolventes

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Prepared analogously to Example 10c from 5-bromo-thiophene-2-carboxylic acid and (R)-2-amino-3-(1H-imidazol-4-yl)-N-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenyl]-propionamide with PPA and NMM in THF.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07732466B2uspto-grants-2010_06