Reacción #433588
ord-5370d7db4ff949b28a752734447fc010
Ecuación de reacción
quinazoline
3,4-dichloro-6-fluoroaniline
4-chloro-6-nitroquinazoline
→
4-[(3,4-dichloro-6-fluorophenyl)amino]-6-nitroquinazoline
Reactivos
Ninguno
Condiciones de reacción
Condiciones detalladas
See reaction.notes.procedure_details.
Procedimiento
In one particular, which includes a quinazoline that is substituted by one reactive group at position 6 thereof, 3,4-dichloro-6-fluoroaniline is reacted with 4-chloro-6-nitroquinazoline, so as to produce 4-[(3,4-dichloro-6-fluorophenyl)amino]-6-nitroquinazoline, which is reduced, by means of an ethanolic solution of hydrazine hydrate and Raney®Nickel, so as to produce 4-[(3,4-dichloro-6-fluorophenyl)amino]-6-aminoquinazoline. Then, the 4-[(3,4-dichloro-6-fluorophenyl)amino]-6-aminoquinazoline is reacted with a carbon-11 labeled acryloyl chloride so as to produce a carbon-11 labeled N-{4-[(3,4-dichloro-6-fluorophenyl)amino]quinazoline-6-yl}acrylamide (carbon-11 labeled Compound 3).