Reacción #43333

Ecuación de reacción

Potassium carbonate

methyl p-toluenesulfonate

DMF

1-{4-[2-(1-pyrrolidinyl)ethoxy]phenyl}-1H-pyridin-2-one

→

title compound

Rendimiento 53.0%

4-[(E)-2-(4-methoxyphenyl)vinyl]-1-{4-[2-(1-pyrrolidinyl]-ethoxy}phenyl)-1H-pyridin-2-one

Rendimiento 53.0%

Disolventes

Ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadoby washing with water and saturated brine
2. 2
   Secadodrying over anhydrous sodium sulfate
3. 3
   ConcentraciónConcentrating
4. 4
   Otrothe reaction liquid under reduced pressure
5. 5
   Otrothe residue was purified on silica gel column chromatography (C-300; methanol:chloroform=1:20-1:10)

Procedimiento

Potassium carbonate (11 mg, 0.08 mmol) and methyl p-toluenesulfonate (6 mg, 0.03 mmol) were added to DMF (2 mL) solution of 4-[(E)-2-4-hydroxyphenyl)vinyl]-1-{4-[2-(1-pyrrolidinyl)ethoxy]phenyl}-1H-pyridin-2-one (11 mg, 0.03 mmol), and stirred for a day and night at 80° C. Ethyl acetate was added to the reaction liquid, followed by washing with water and saturated brine and drying over anhydrous sodium sulfate. Concentrating the reaction liquid under reduced pressure, the residue was purified on silica gel column chromatography (C-300; methanol:chloroform=1:20-1:10) to provide the title compound (6 mg, 53%) as a white solid.

Fuente