Reacción #43311

Ecuación de reacción

4-Benzyloxy-1-(4-hydroxyphenyl)-1H-pyridin-2-one

2-(dimethylamino)ethanol

triphenylphosphine

diethyl azodicarboxylate

→

title compound

Rendimiento 66.6%

4-benzyloxy-1-{4-[2-(dimethylamino)ethoxy]phenyl}-1H-pyridin-2-one

Rendimiento 66.6%

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónConcentrating
2. 2
   Otrothe reaction liquid under reduced pressure
3. 3
   Otrothe resulting residue was purified on silica gel column chromatography (C-300, methanol: chloroform=1:20-1:10)

Procedimiento

4-Benzyloxy-1-(4-hydroxyphenyl)-1H-pyridin-2-one (150 mg, 0.511 mmol), 2-(dimethylamino)ethanol (0.057 mL, 0.562 mmol), triphenylphosphine (269 mg, 1.02 mmols) and diethyl azodicarboxylate (0.163 mL, 1.02 mmols) were stirred overnight in THF (4 mL). Concentrating the reaction liquid under reduced pressure, the resulting residue was purified on silica gel column chromatography (C-300, methanol: chloroform=1:20-1:10) to provide the title compound (124 mg, 60%).

Fuente