Reacción #43185

Ecuación de reacción

3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde

intermediate 1

3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde

tert butylamine

→

tert-Butyl-[3-(2-chloro-pyrimidin-4-yl)-benzyl]-amine

Rendimiento 97.0%

Condiciones de reacción

Procedimiento

3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde (intermediate 1) and tert butylamine were coupled by procedure B. The yield was 97%. LC-MS showed the product had the expected M+H+ of 276. 1H NMR (Varian 300 MHz, CDCl3, shifts relative to the solvent peak at 7.24 ppm) 8.6 (d, 1H) 8.1 (s, 1H) 7.9 (d, 1H) 7.6 (d, 1H) 7.5 (m, 2H) 1.2 (s, 9H).

Fuente