Reacción #4303

Ecuación de reacción

Ether

benzyl 2-chloroethyl sulfone

isopropylamine

hydrogen chloride

→

white crystalline solid

Rendimiento 65.8%

N-[2-[(Phenylmethyl)sulfonyl]ethyl]-2-propanamine hydrochloride

Rendimiento 65.8%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solvent was removed in vacuo
2. 2
   Otrothe residue was partitioned between ether and dilute sodium hydroxide
3. 3
   SecadoThe ether solution was dried over magnesium sulfate
4. 4
   Otrothe solvent was removed in vacuo
5. 5
   Otroto give an oil
6. 6
   Otroa white solid precipitated

Procedimiento

A mixture of 51.49 g (0.236 mole) of benzyl 2-chloroethyl sulfone and 600 ml of isopropylamine was stirred at room temperature for 72 hr. The solvent was removed in vacuo, and the residue was partitioned between ether and dilute sodium hydroxide. The ether solution was dried over magnesium sulfate, and the solvent was removed in vacuo to give an oil. This was dissolved in methanol, and excess ethereal hydrogen chloride was added. Ether was added, and a white solid precipitated to give 43.11 g (65.8%) of a white crystalline solid, m.p. 180.5°-181.5° C.

Fuente