Reacción #43023

Ecuación de reacción

Intermediate 6

3-(2-Chloro-pyrimidin-4-yl)-phenylamine

3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester

→

3-[3-(2-Chloro-pyrimidin-4-yl)-phenylamino]-pyrrolidine-1-carboxylic acid tert-butyl ester

Rendimiento 70.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe product was purified on silica gel using 1:1 ethyl acetate

Procedimiento

Intermediate 6 was coupled with 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester following procedure J. The product was purified on silica gel using 1:1 ethyl acetate:hexanes as eluent. Yield: 70%. LC-MS showed the product had the expected M+H+ of 375.

Fuente