Reacción #4301

Ecuación de reacción

[(4-chlorobutyl)sulfonyl]benzene

isopropylamine

→

N-(1-Methylethyl)-4-(phenylsulfonyl)-1-butanamine hydrochloride

Rendimiento 30.0%

Disolventes

chloroform

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe residue obtained
2. 2
   Extracciónthe chloroform layer was extracted with water
3. 3
   SecadoThe chloroform layer was dried
4. 4
   Filtraciónfiltered
5. 5
   Otrosolvent removed
6. 6
   Otroto give a dark brown oil
7. 7
   OtroThis salt was recrystallized from methanol-diethyl ether
8. 8
   Otrodried in vacuo overnight at 80° C

Procedimiento

A solution of 105.95 g (0.456 mole) [(4-chlorobutyl)sulfonyl]benzene was heated overnight at 75° C. on an autoclave in 200 ml of isopropylamine. The reaction mixture was stripped to dryness. The residue obtained was dissolved in chloroform and the chloroform layer was extracted with water. The chloroform layer was dried, filtered, and solvent removed to give a dark brown oil. The oil was dissolved in methanol and converted to the hydrochloride salt. This salt was recrystallized from methanol-diethyl ether and dried in vacuo overnight at 80° C. This gave white crystalline product, m.p. 155°-157.5° C. in 30% yield.

Fuente