Reacción #4297

Ecuación de reacción

2-chloroethylphenyl sulfone

methylamine

→

title compound

N-Methyl-2-(phenylsulfonyl)ethanamine

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solvent is removed in vacuo
2. 2
   Otrothe residue is partitioned between methylene chloride and dilute sodium hydroxide
3. 3
   ExtracciónThe methylene chloride solution is extracted with dilute sulfuric acid
4. 4
   ExtracciónThe acidic extract
5. 5
   Extracciónthe basic solution is extracted with methylene chloride
6. 6
   SecadoThe methylene chloride solution is dried over magnesium sulfate
7. 7
   Otrothe solvent is removed in vacuo

Procedimiento

A solution of 2-chloroethylphenyl sulfone and a large excess of methylamine (40% solution in water) in acetonitrile is stirred at room temperature overnight. The solvent is removed in vacuo and the residue is partitioned between methylene chloride and dilute sodium hydroxide. The methylene chloride solution is extracted with dilute sulfuric acid. The acidic extract is made basic with 50% sodium hydroxide and the basic solution is extracted with methylene chloride. The methylene chloride solution is dried over magnesium sulfate and the solvent is removed in vacuo to give the title compound.

Fuente