Reacción #42915

Ecuación de reacción

[4-(1,3-dihydro-isoindole-2-carbonyl)-6,8-dimethoxy-isoquinolin-1-ylmethyl]-carbamic acid tert-butyl ester

HCl

→

(1-aminomethyl-6,8-dimethoxy-isoquinolin-4-yl)-(1,3-dihydro-isoindol-2-yl)-methanone hydrochloride

Rendimiento 100.0%

Disolventes

EtOAc

Condiciones de reacción

Procedimiento

As described in example 1, 61 mg of [4-(1,3-dihydro-isoindole-2-carbonyl)-6,8-dimethoxy-isoquinolin-1-ylmethyl]-carbamic acid tert-butyl ester was treated with HCl in EtOAc to give 59 mg (>100%) of (1-aminomethyl-6,8-dimethoxy-isoquinolin-4-yl)-(1,3-dihydro-isoindol-2-yl)-methanone hydrochloride. H1-NMR (DMSO): δ, 8.49 (s, 1H), 8.43 (br s, 3H), 7.42-7.15 (m, 4H), 6.85 (s, 1H), 6.74 (s, 1H), 4.97 (s, 2H), 4.70 (d, J=4.7 Hz, 2H), 4.49 (s, 2H), 3.99 (s, 3H), 3.82 (s, 3H); MS: APCI (M+H) calc'd for C21H21N3O3+H 364.4; found 364.2.

Fuente