Reacción #42894

ord-cdfd5a0361c44990bc9d91a1987e4e5e

Ecuación de reacción

COC(=O)c1cscc1NC(=O)C(F)Cl
4-(2-chloro-2-fluoro-acetylamino)-thiophene-3-carboxylic acid methyl ester
Oc1ccc(-c2ccc(F)cc2)cc1
4-fluoro-4′-hydroxybiphenyl
→
O=C(O)c1cscc1NC(=O)C(F)Oc1ccc(-c2ccc(F)cc2)cc1
title compound
O=C(O)c1cscc1NC(=O)C(F)Oc1ccc(-c2ccc(F)cc2)cc1
Rac-4-[2-Fluoro-2-(4′-fluoro-biphenyl-4-yloxy)-acetylamino]-thiophene-3-carboxylic acid

Reactantes

COC(=O)c1cscc1NC(=O)C(F)Cl
4-(2-chloro-2-fluoro-acetylamino)-thiophene-3-carboxylic acid methyl ester
Oc1ccc(-c2ccc(F)cc2)cc1
4-fluoro-4′-hydroxybiphenyl

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

In analogy to Example 2, the title compound was prepared using 4-(2-chloro-2-fluoro-acetylamino)-thiophene-3-carboxylic acid methyl ester and 4-fluoro-4′-hydroxybiphenyl. MS (m/e): 388.2 (M−H).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07732452B2uspto-grants-2010_06