Reacción #428851

Ecuación de reacción

sulfuric acid

3,6-dimethyl-oct-4-yne-3,6-diol

→

2,5-diethyl-2,5-di-methyldihydrofuran-3-one

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction mixture is maintained at 80° C. for 4 hours
2. 2
   Temperaturato cool to ambient temperature
3. 3
   ExtracciónThe mixture is extracted with diethyl ether (3×150 ml)
4. 4
   Lavadowashed with water
5. 5
   Secadodried over anhydrous sodium sulfate
6. 6
   FiltraciónThe mixture is filtered
7. 7
   Otrothe filtrate is evaporated under reduced pressure

Procedimiento

A mixture of mercury (II) acetate (2.7 g, 0.0084 mol), sulfuric acid (2.7 ml, 0.027 mol), water (270 ml) and 3,6-dimethyl-oct-4-yne-3,6-diol (27.0 g, 0.159 mol) is heated at 80° C. The reaction mixture is maintained at 80° C. for 4 hours and allowed to cool to ambient temperature. The mixture is extracted with diethyl ether (3×150 ml), the organic phases are combined, washed with water, and dried over anhydrous sodium sulfate. The mixture is filtered and the filtrate is evaporated under reduced pressure to give 2,5-diethyl-2,5-di-methyldihydrofuran-3-one (20 g) as a colourless oil.

Fuente