Reacción #42837

ord-d976352f2ebb4c96abede001169aa40a

Ecuación de reacción

CC#CCOc1cc(Cl)ncn1
4-chloro-6-(2-butynyloxy)pyrimidine
C1=CCNCC1
1,2,3,6-tetrahydropyridine
CC#CCOc1cc(N2CC=CCC2)ncn1
1-(6-(2-butynyloxy)pyrimidin-4-yl)-1,2,3,6-tetrahydropyridine
Rendimiento 100.9%

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

0.3 g of 4-chloro-6-(2-butynyloxy)pyrimidine and 0.41 g of 1,2,3,6-tetrahydropyridine were mixed and left for 2 hours at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.38 g of 1-(6-(2-butynyloxy)pyrimidin-4-yl)-1,2,3,6-tetrahydropyridine (hereinafter, referred to as Compound (54)).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07732448B2uspto-grants-2010_06