Reacción #42727

Ecuación de reacción

4-hydroxyphenethyl alcohol

potassium carbonate

1,3 dibromopropane

→

title compound

Rendimiento 77.3%

2-[4-(3-Bromopropoxy)phenyl]ethanol

Rendimiento 77.3%

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturacooled to room temperature
2. 2
   Filtraciónfiltered
3. 3
   Concentraciónconcentrated under vacuum
4. 4
   OtroThe resulting oil was purified by silica gel chromatography
5. 5
   workup.ADDITIONa mixture of 4:1 hexanes and ethyl acetate

Procedimiento

To a solution of 4-hydroxyphenethyl alcohol (4.37 g, 31.0 mmol) and potassium carbonate (6.55 g, 47.0 mmol) in acetonitrile (62.0 mL) was added 1,3 dibromopropane (31.0 mL, 316 mmol). The reaction mixture was heated to 70° C. for 12 hours and then cooled to room temperature, filtered and concentrated under vacuum. The resulting oil was purified by silica gel chromatography using a mixture of 4:1 hexanes and ethyl acetate to give the title compound (6.21 g) as a white solid.

Fuente