Reacción #42534

Ecuación de reacción

7-bromo-1-chloroisoquinoline

→

7-bromo-2-(N-propylamino)isoquinoline

Disolventes

propylamine

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe reaction mixture was concentrated under reduced pressure
2. 2
   workup.DISSOLUTIONdissolved in chloroform
3. 3
   Lavadowashed with saturated sodium bicarbonate, saturated sodium chloride
4. 4
   Secadodried (sodium sulfate)
5. 5
   Filtraciónfiltered
6. 6
   Concentraciónconcentrated under reduced pressure

Procedimiento

A solution of 7-bromo-1-chloroisoquinoline in propylamine (15.0 mL) was heated at 70° C. in a sealed tube overnight. The reaction mixture was concentrated under reduced pressure, then dissolved in chloroform and washed with saturated sodium bicarbonate, saturated sodium chloride, dried (sodium sulfate), filtered, and concentrated under reduced pressure to yield 7-bromo-2-(N-propylamino)isoquinoline (820 mg): ESI MS m/z 266 [M+H]+.

Fuente