Reacción #4239

Ecuación de reacción

2-(chloromethyl)benzenesulfonamide

pyrrolidine

→

white solid

Rendimiento 92.8%

2-(1-Pyrrolidinylmethyl)benzenesulfonamide

Rendimiento 92.8%

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe volatiles were removed under vacuum
2. 2
   workup.ADDITIONthe residue was treated with water (40 ml)
3. 3
   Temperaturachilled
4. 4
   Filtraciónfiltered
5. 5
   Otrodried

Procedimiento

A solution of 2-(chloromethyl)benzenesulfonamide (2.00 g, 10 mmol) in acetonitrile (20 ml) was contacted with pyrrolidine (1.6 ml, 20 mmol). After 1.0 hr at ambient temperature, the volatiles were removed under vacuum and the residue was treated with water (40 ml) and chilled. The resulting solid was pulverized, filtered, and dried to give 2.23 g of white solid, m.p. 110°-112°.

Fuente