Reacción #42355

Ecuación de reacción

O-benzyl-N-(tert-butoxycarbonyl)homoserine

trimethylsilyldiazomethane

hexane

→

title compound

Methyl O-benzyl-N-(tert-butoxycarbonyl)homoserinate

Disolventes

methanol benzene

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe solution is concentrated under reduced pressure

Procedimiento

To O-benzyl-N-(tert-butoxycarbonyl)homoserine (5.8 g, 18.9 mmol) in 20% methanol/benzene (72 mL) is added 2M trimethylsilyldiazomethane in hexane (12.3 mL, 24.5 mmol), and the reaction stirred at room temperature 1.5 h. The solution is concentrated under reduced pressure to give the title compound in pure form. ESI MS m/z 324.2 [M+H]+.

Fuente