Reacción #423202

ord-737428b6fb1c48239fe75b06900d6372

Ecuación de reacción

NC1=N[C@@]2(CS1)c1cc(Br)ccc1Oc1c(F)cc(O)cc12
(S)-2-amino-7′-bromo-4′-fluoro-5H-spiro[thiazole-4,9′-xanthen]-2′-ol
OB(O)c1cccnc1F
2-fluoropyridin-3-ylboronic acid
Cl.FC1(F)CCNCC1
4,4-difluoropiperidine hydrochloride
NC1=N[C@@]2(CS1)c1cc(-c3cccnc3F)ccc1Oc1c(F)cc(N3CCC(F)(F)CC3)cc12
titled compound
NC1=N[C@@]2(CS1)c1cc(-c3cccnc3F)ccc1Oc1c(F)cc(N3CCC(F)(F)CC3)cc12
(S)-2′-(4,4-difluoropiperidin-1-yl)-4′-fluoro-7′-(2-fluoropyridin-3-yl)-5H-spiro[thiazole-4,9′-xanthen]-2-amine

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

The titled compound was synthesized by stpes analogous to those described in method AA20 above, but using (S)-2-amino-7′-bromo-4′-fluoro-5H-spiro[thiazole-4,9′-xanthen]-2′-ol (prepared as described in Method BB26 and Example 2 but using 7-bromo-4-fluoro-2-methoxy-9H-xanthen-9-one), 2-fluoropyridin-3-ylboronic acid and 4,4-difluoropiperidine hydrochloride. MS m/z=501.0.0 [M+H]+.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US08883782B2uspto-grants-2014_11