Reacción #42303
ord-20201984300a44be9a2d0db57120a64f
Ecuación de reacción
3-(cyanomethyl)-5-[(dipropylamino)carbonyl]benzoic acid
3-(aminocarbonyl)-5-[(dipropylamino)carbonyl]benzoic acid
(2R,3S)-3-amino-1-[(3-methoxybenzyl)amino]-4-phenyl-2-butanol
(2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-[(3-methoxybenzyl)amino]-2-butanol trifluoroacetate
HATU
→
title compound
N1-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-(cyanomethyl)-N3,N3-dipropylisophthalamide
Reactantes
Reactivos
Ninguno
Disolventes
Condiciones de reacción
Temperatura
40°CELSIUS
Condiciones detalladas
See reaction.notes.procedure_details.
Tratamiento posterior
- 1Otroovernight
- 2TemperaturaAfter cooling
- 3Lavadothe mixture is washed with water
- 4Otrothe organic phase is separated
- 5Secadodried over magnesium sulfate
Procedimiento
A mixture of 3-(cyanomethyl)-5-[(dipropylamino)carbonyl]benzoic acid (IX, 0.13 g), (2R,3S)-3-amino-1-[(3-methoxybenzyl)amino]-4-phenyl-2-butanol (VIII, 0.14 g), HATU (0.17 g), and dichloromethane (10 mL) is stirred at 40 degrees C. overnight. After cooling, the mixture is washed with water and the organic phase is separated and dried over magnesium sulfate and taken to dryness under reduced pressure. Chromatography (silica gel) gives the title compound, M+H=571.2