Reacción #42218

Ecuación de reacción

(±)-3-[1-(benzyloxy)-4-chloro-2-naphthyl]propane-1,2-diol

p-toluenesulfonyl chloride

→

(±)-3-[1-(benzyloxy)-4-chloro-2-naphthyl]-2-hydroxypropyl 4-methylbenzenesulfonate

Rendimiento 80.2%

Disolventes

pyridine

Condiciones de reacción

Procedimiento

Treatment of (±)-3-[1-(benzyloxy)-4-chloro-2-naphthyl]propane-1,2-diol (24 g, 0.07 mol) with p-toluenesulfonyl chloride (14 g, 0.074 mol) in pyridine (600 mL) generally according to the procedure described for Intermediate 18 gave 27.9 g (80%) of (±)-3-[1-(benzyloxy)-4-chloro-2-naphthyl]-2-hydroxypropyl 4-methylbenzenesulfonate as a white solid. mp 85-87° C.; Anal. calcd. for C27H25ClO5S: C, 65.25; H, 5.07. Found: C, 65.37; H, 4.97.

Fuente