Reacción #4209

Ecuación de reacción

2-chloro-N-[3,4-bis(phenylmethoxy)phenyl]acetamide

sodium iodide

→

title compound

Rendimiento 60.4%

2-Iodo-N-[3,4-bis(phenylmethoxy)phenyl]acetamide

Rendimiento 60.4%

Disolventes

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe reaction was filtered hot
2. 2
   Otroto remove the sodium iodide
3. 3
   Otroa precipitate formed in the cold filtrate which
4. 4
   Otrowas collected
5. 5
   Lavadowashed with cold acetone
6. 6
   Otroto give
7. 7
   Otroupon drying

Procedimiento

A solution of 2-chloro-N-[3,4-bis(phenylmethoxy)phenyl]acetamide (8.98 g, 23.5 mmol) and sodium iodide (3.53 g, 23.5 mmol) in acetone (75 ml) was refluxed for two hours and allowed to stand overnight at room temperature. The reaction was filtered hot to remove the sodium iodide and a precipitate formed in the cold filtrate which was collected and washed with cold acetone to give, upon drying, 6.71 g (14.2 mmol) of the title compound. A second crop was obtained from cold acetone (1.0 g).

Fuente