Reacción #41998

Ecuación de reacción

N-{3-[5-fluoro-1-(3-iodo-propyl)-indan-1-yl]-1H-indol-7-yl}-methane sulfonamide

morpholine

→

title compound

Rendimiento 83.0%

N-{3-[5-Fluoro-1-(3-morpholin-4-yl-propyl)-indan-1-yl]-1H-indol-7-yl}-methanesulfonamide

Rendimiento 83.0%

Disolventes

tetrahydrofuran

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroRemove the volatiles under high vacuum
2. 2
   workup.DISSOLUTIONdissolve the residue in dichloromethane
3. 3
   workup.ADDITIONadd solid potassium carbonate
4. 4
   Filtraciónfilter
5. 5
   Concentraciónconcentrate in vacuo
6. 6
   OtroPurify the residue on silica eluting with 5 to 10% methanol in dichloromethane over 15 minutes

Procedimiento

Combine N-{3-[5-fluoro-1-(3-iodo-propyl)-indan-1-yl]-1H-indol-7-yl}-methane sulfonamide (65 mg, 0.13 mmol) and morpholine (2 ml) in anhydrous tetrahydrofuran (2.5 ml) and stir at room temperature under nitrogen overnight. Remove the volatiles under high vacuum, dissolve the residue in dichloromethane, add solid potassium carbonate, stir for ten minutes, filter, and concentrate in vacuo. Purify the residue on silica eluting with 5 to 10% methanol in dichloromethane over 15 minutes to obtain the title compound as a white solid (50 mg, 83%). LC-MS m/z 472.2 (M++1).

Fuente