Reacción #41991

Ecuación de reacción

3-(1-ethyl-5-fluoro-indan-1-yl)-1H-indol-7-ylamine

methyl chloroformate

→

title compound

Rendimiento 36.0%

[3-(1-Ethyl-5-fluoro-indan-1-yl)-1H-indol-7-yl]-carbamic acid methyl ester

Rendimiento 36.0%

Disolventes

ether

pyridine

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadowash with 1N aqueous hydrochloric acid (2×)
2. 2
   Secadodry over anhydrous sodium sulfate
3. 3
   Filtraciónfilter
4. 4
   Concentraciónconcentrate solution in vacuo
5. 5
   OtroPurify the residue on silica eluting with 0 to 75% ethyl acetate/hexanes over 30 minutes

Procedimiento

Dissolve 3-(1-ethyl-5-fluoro-indan-1-yl)-1H-indol-7-ylamine (0.35 g, 1.19 mmol) in pyridine (3 ml). Add methyl chloroformate (0.10 ml, 1.31 mmol, 1.1 equivalents) and stir at room temperature under nitrogen overnight. Dilute with ether, wash with 1N aqueous hydrochloric acid (2×), dry over anhydrous sodium sulfate, filter, and concentrate solution in vacuo. Purify the residue on silica eluting with 0 to 75% ethyl acetate/hexanes over 30 minutes to provide the title compound as a white solid (0.15 g, 36%). LC-MS m/z 353.1 (M++1).

Fuente