Reacción #41965

Ecuación de reacción

triphenylphosphine

3-bromopropionic acid

ether

→

title compound

Rendimiento 68.5%

(2-Carboxy-ethyl)-triphenyl-phosphonium bromide

Rendimiento 68.5%

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónFilter solids
2. 2
   Lavadorinse with ether
3. 3
   Otrodry solids under high vacuum

Procedimiento

Reflux a solution of triphenylphosphine (91.3 g, 348 mmol, 1.05 equivalents) and 3-bromopropionic acid (50.7 g, 331 mmol) in acetonitrile (250 ml) for three hours, allow to sit at room temperature overnight. Add ether (400 ml) and cool in the freezer for two hours. Filter solids, rinse with ether, and dry solids under high vacuum to obtain the title compound (94.1 g, 68%). NMR (400 MHz, CDCl3): δ 3.15 (m, 2H), 3.73 (m, 2H), 7.69-7.83 (m, 15H).

Fuente