Reacción #41956

Ecuación de reacción

Chloroacetaldehyde diethyl acetal

potassium benzoate

potassium bromide

DMF

→

compound

Rendimiento 34.1%

2-benzoyloxyacetaldehyde Diethyl Acetal

Rendimiento 34.1%

Disolventes

ethyl acetate

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaby refluxing
2. 2
   FiltraciónAfter filtration
3. 3
   Lavadothe organic layer was washed with water (30 mL)
4. 4
   Secadowas dried over anhydrous sodium sulfate
5. 5
   FiltraciónSubsequent filtration and vacuum concentration

Procedimiento

Chloroacetaldehyde diethyl acetal (2.00 g), potassium benzoate (1.91 g), potassium bromide (0.30 g) and DMF (20 mL) were placed in a three-neck flask, followed by refluxing. Twenty hours later, the reaction mixture was cooled to room temperature, and water (30 mL) and ethyl acetate (80 mL) were added thereto, followed by stirring. After filtration, the organic layer was washed with water (30 mL) and was dried over anhydrous sodium sulfate. Subsequent filtration and vacuum concentration yielded the target compound (0.97 g) in a yield of 31%.

Fuente