Reacción #41827

Ecuación de reacción

4-carboxybenzaldehyde

thionyl chloride

DMF

→

title compound

4-Formyl-benzoyl chloride

Disolventes

toluene

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.DISSOLUTIONdissolved
2. 2
   Otroto yield a pale yellow colored solution
3. 3
   TemperaturaThe reaction mixture was cooled to 0° C.

Procedimiento

A solution of 4-carboxybenzaldehyde (30.0 g, 0.200 mol) in toluene (300 mL) was treated with thionyl chloride (28.6 g, 0.240 mol) and DMF (1.0 mL). The reaction mixture was heated at 100° C. for 2 h, during which time the solids dissolved to yield a pale yellow colored solution. The reaction mixture was cooled to 0° C. to yield a solution of the title compound in toluene, which was used without further manipulation.

Fuente