Reacción #41813

Ecuación de reacción

4-formyl-benzoyl chloride

4-Formyl-benzoyl chloride

toluene

NaHCO3

4-isopropylpiperazine

water

→

title compound

4-(4-Isopropyl-piperazine-1-carbonyl)-benzaldehyde

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe layers were split
2. 2
   Concentraciónthe toluene phase was concentrated

Procedimiento

A solution of 4-formyl-benzoyl chloride (2.80, 16.65 mol) (prepared as in Example 1 above) in toluene (43.3 g, 469.39 mmol) was added slowly to a solution of NaHCO3 (0.8 g, 9.52 mmol) and 4-isopropylpiperazine (2.50 g, 18.35 mmol) in water (5 g, 277 mmol) at 0° C. The reaction mixture was vigorously stirred until the reaction was deemed complete. The layers were split and the toluene phase was concentrated to yield the title compound as a yellow oil.

Fuente