Reacción #417970

Ecuación de reacción

Acetic acid

25b

1-bromo-4-nitro-2-(2-phenoxy-ethoxy)-benzene

→

aniline

Rendimiento 84.0%

4-bromo-3-(2-phenoxy-ethoxy)-phenylamine

Rendimiento 84.0%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe mixture was filtered
2. 2
   workup.DISTILLATIONthe solvent distilled off under reduced pressure
3. 3
   Otrothe crude was purified by flash column chromatography

Procedimiento

Acetic acid (1.068 mL, 18 mmol) was added to the mixture of 25b (600 mg, 1.8 mmol) and zinc dust (1.157 g, 18.0 mmol) in ethanol (10 mL) at 0° C. The reaction mixture was warmed to room temperature and stirred for 4 hrs. The mixture was filtered, the solvent distilled off under reduced pressure and the crude was purified by flash column chromatography to obtain the aniline 25c in 84% yield.

Fuente