Reacción #417964

Ecuación de reacción

Acetic anhydride

4-chloro-3-hydroxy aniline

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product 17a

Rendimiento 93.0%

N-(4-chloro-3-hydroxyphenyl)acetamide

Rendimiento 93.0%

Disolventes

acetic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe reaction was refluxed for 5 mins
2. 2
   FiltraciónIt was filtered off
3. 3
   Lavadowashed with water (10 mL)
4. 4
   Otrodried

Procedimiento

Acetic anhydride (3.0 mL, 42.0 mmol) was added to a solution of 4-chloro-3-hydroxy aniline (4.0 g, 28 mmol) in acetic acid (20 mL), and the reaction was refluxed for 5 mins. The reaction mixture was cooled to room temperature and the product was solidified. It was filtered off and washed with water (10 mL) and dried to obtain the product 17a in 93% yield (4.8 g) as a creamy white solid. There was no need for further purification.

Fuente